Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

Dennis Huszar, Catherine Lynch, Victoria Fairchild-Huntress et al. · Cell · 1997 · 3K citations · Full text

Obesity, Metabolic Syndrome, Energy Homeostasis +12

Congenital leptin deficiency is associated with severe early-onset obesity in humans

I. Sadaf Farooqi, Jonathan P. Whitehead, Maria A. Soos et al. · Nature · 1997 · 2.9K citations · Full text

Obesity, Metabolic Syndrome, Nutrition +10

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

Heiko Krude, Heike Biebermann, W. A. P. Luck et al. · Nature Genetics · 1998 · 1.7K citations

Obesity, Metabolic Syndrome, Severe Early-onset Obesity +8

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

Andrew A. Butler, Robert A. Kesteson, Kathy Khong et al. · Endocrinology · 2000 · 680 citations · Full text

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

Jürgen Κ. Naggert, Lloyd D. Fricker, Oleg Varlamov et al. · Nature Genetics · 1995 · 667 citations

Obesity, Metabolic Syndrome, Carboxypeptidase E Mutation +12