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Stereochemistry and absolute configuration of the antibiotic spectinomycin: an X-ray diffraction study
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1972
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X-ray CrystallographyStable Ketone HydrateCrystal StructureEngineeringOrganic ChemistryX-ray Diffraction StudyAntimicrobial ChemotherapySpectra-structure CorrelationDrug ResistanceAnomalous DispersionStructure ElucidationStereoselective SynthesisSpectinomycin Dihydrobromide PentahydrateAntimicrobial ResistanceBiophysicsAbsolute ConfigurationBiochemistryAntimicrobial CompoundPharmacologyCrystallographyCrystal Structure DesignAntibiotic SpectinomycinAntibioticsMedicine
A single crystal X-ray diffraction study of spectinomycin dihydrobromide pentahydrate has shown that the molecule has a B/Ccis ring juncture and exists as a stable ketone hydrate; the absolute configuration of the molecule was determined by anomalous dispersion.