Journal of the Chemical Society Chemical Communications · 1972 · 36 citations · 0 references
X-ray CrystallographyStable Ketone HydrateCrystal StructureEngineeringOrganic ChemistryX-ray Diffraction StudyAntimicrobial ChemotherapySpectra-structure CorrelationDrug ResistanceAnomalous DispersionStructure ElucidationStereoselective SynthesisSpectinomycin Dihydrobromide PentahydrateAntimicrobial ResistanceBiophysicsAbsolute ConfigurationBiochemistryAntimicrobial CompoundPharmacologyCrystallographyCrystal Structure DesignAntibiotic SpectinomycinAntibioticsMedicine
A single crystal X-ray diffraction study of spectinomycin dihydrobromide pentahydrate has shown that the molecule has a B/Ccis ring juncture and exists as a stable ketone hydrate; the absolute configuration of the molecule was determined by anomalous dispersion.