Specific Inhibition of RH <sub>0</sub> (D) Antibody by Sialic Acids

Matthew C. Dodd, Nancy J. Bigley, Virginia B. Geyer

Science · 1960 · 20 citations · 3 references

Concepts

Abstract

Agglutination of Rh(O)(D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. A brain ganglioside containing neuraminic acid and a Pseudomonas polysaccharide were even more inhibitory. Inhibition was specific for anti-D sera.

References

3