Concepedia

Fetal Insulin and IGF-II Contribute to Gestational Diabetes Mellitus (GDM)-Associated Up-Regulation of Membrane-Type Matrix Metalloproteinase 1 (MT1-MMP) in the Human Feto-Placental Endothelium

Ursula Hiden, Luciana Lassance, Nassim Ghaffari‐Tabrizi‐Wizsy, Heidi Miedl, Carmen Tam‐Amersdorfer, Irene Cetin, Undine E. Lang, Gernot Desoyé

The Journal of Clinical Endocrinology & Metabolism · 2012 · 65 citations · 31 references

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Abstract

GDM up-regulates MT1-MMP in the feto-placental endothelium, and insulin and IGF-II contribute. This may account for GDM-associated changes in the feto-placental vasculature.

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