ε-(γ-Glutamyl)lysine in Fibrin: Lack of Crosslink Formation in Factor XIII Deficiency

Abstract

Fibrin clots formed in normal plasma contained about 6 mol of epsilon-(gamma-glutamyl)lysine per mol of fibrin, whereas those formed in plasma from individuals with Factor XIII deficiency contained little or none of this crosslink (0.02-0.64 mol/mol of fibrin). Partial supplementation of the plasma with Factor XIII, at a single concentration tested, commensurately increased the number of crosslinks.