Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion

A synthetic oscillatory network of transcriptional regulators

Michael B. Elowitz, Stanislas Leibler · Nature · 2000 · 4.8K citations

Life Sciences, Genetics, Molecular Biology +14

Construction of a genetic toggle switch in Escherichia coli

Timothy S. Gardner, Charles R. Cantor, James J. Collins · Nature · 2000 · 4.4K citations

Life Sciences, Genetics, Microbiology +13

Transcriptional Activation by Tetracyclines in Mammalian Cells

Manfred Gossen, Sabine Freundlieb, Gabriele Bender et al. · Science · 1995 · 2.5K citations

Life Sciences, Molecular Biology, Molecular Genetics +17

Engineering stability in gene networks by autoregulation

Attila Becskei, Luís Serrano · Nature · 2000 · 1.6K citations

Life Sciences, Genetics, Molecular Biology +12

The Biochemical Basis of an All-or-None Cell Fate Switch in <i>Xenopus</i> Oocytes

James E. Ferrell, Eric M. Machleder · Science · 1998 · 1.1K citations

Life Sciences, Biochemistry, Cell Biology +17