Concepedia

Mechanism of resistance to some cephalosporins in Staphylococcus aureus

Mari Kono, Masanori Sasatsu, Koji Ohara, Yasuki Shiomi, T Hayasaka

Antimicrobial Agents and Chemotherapy · 1983 · 14 citations · 5 references

DOI

Concepts

Abstract

The mechanism of resistance to some cephalosporins in Staphylococcus aureus strains was investigated with high-pressure liquid chromatography and nuclear magnetic resonance spectrometry. Drug inactivation by penicillinase was found to be the main mechanism of resistance to cefazolin, cephaloridine, and cephalothin in S. aureus.

References

5

Decreased affinity of a penicillin-binding protein for β-lactam antibiotics in a clinical isolate of<i>Staphylococcus aureus</i>resistant to methicillin

Michael V. Hayes, Nigel A. C. Curtis, Anne W. Wyke et al. · FEMS Microbiology Letters · 1981 · 105 citations · Full text

, , +11

Penicillin-binding proteins in a Staphylococcus aureus strain resistant to specific beta-lactam antibiotics

N H Georgopapadakou, Sandra Smith, D P Bonner · Antimicrobial Agents and Chemotherapy · 1982 · 101 citations

, , +17

Binding of beta-lactam antibiotics to penicillin-binding proteins of Staphylococcus aureus and Streptococcus faecalis: relation to antibacterial activity

N H Georgopapadakou, F Y Liu · Antimicrobial Agents and Chemotherapy · 1980 · 99 citations · Full text

, , +11

Comparative activities of 13 beta-lactam antibiotics

H L Muytjens, J van der Ros-van de Repe · Antimicrobial Agents and Chemotherapy · 1982 · 82 citations

, , +13

Cefotetan, a new cephamycin: comparison of in vitro antimicrobial activity with other cephems, beta-lactamase stability, and preliminary recommendations for disk diffusion testing

Leona W. Ayers, Ronald N. Jones, A L Barry et al. · Antimicrobial Agents and Chemotherapy · 1982 · 47 citations · Full text

, , +14