Gastrin‐Like Activity in Different Parts of the Gastro‐Intestinal Tract of the Cat

Abstract

Abstract Mucosal specimens from different parts of the gastro‐intestinal tract of cats were extracted for gastrin according to the method of Komarov. Extracts were also prepared from the mucosa of the antrum and proximal duodenum according to a modification of a method of Gregory and Tracy. The extracts were assayed for gastrin activity on nonanesthetized gastric fistula cats. Gastrin‐like activity was found in the mucosa of the antrum and the proximal duodenum using either method of extraction. Gastrin‐like activity was also found in most extracts from the cardiac region of the stomach. The gastrin‐like activity of the extracts from the cardiac region and the proximal duodenum was 5–10 per cent of the antral activity. No gastrin‐like activity was detected in the acid secreting part of the stomach, in the middle and distal parts of the duodenum, in the jejunum, colon or pancreas.