Neuroendocrinology · 2008 · 42 citations · 0 references
MedicineEndocrinologyPharmacologyNeuroendocrinologyNeuropharmacologyReproductive EndocrinologyEndocrine PharmacologyEndocrine PhysiologyHormone SignalingNeuroendocrine PharmacologyNeuroendocrine PhysiologyReproductive NeuroendocrinologyAdenosine TriphosphatasesAdrenergic Receptor AgonistsAdrenergic Receptor AntagonistsAdrenergic Receptor SignalingCyclic Adenosine Monophosphate PathwayCyclic Adenosine Monophosphate SignalingEstrogen PharmacologyIntraperitoneal Administration
The effect of an intraperitoneal injection of estradiol benzoate (EB) upon cyclic AMP accumulation in the hypothalamus of 21-day-old rats was studied. Clomiphene citrate administration prior to EB neutralized the estrogen-induced accumulation of hypothalamic cyclic AMP. The increase in cyclic AMP caused by EB was abolished by prior treatment with adrenergic receptor blockers. These results suggest the involvement of adrenergic receptor mechanism(s) in the transmission of the estrogen stimulus in the hypothalamus.