Phenol Ugi–Smiles Systems: Strategies for the Multicomponent N<i>‐</i>Arylation of Primary Amines with Isocyanides, Aldehydes, and Phenols

Abstract

A Smiles rearrangement is the key step in the efficient coupling of primary amines with isocyanides, carbonyl compounds, and electron-deficient substituted phenols to form N-aryl amines (see picture). The presence of a nitro or ester group on the resulting adduct allows applications in heterocyclic synthesis.