Wegener's Granulomatosis

Abstract

Article1 October 1963Wegener's GranulomatosisA Clinico-pathologic Study of Four CasesDAVID A. BERMAN, M.D., ROBERT E. RYDELL, M.D., ALFRED EICHENHOLZ, M.D.DAVID A. BERMAN, M.D.Search for more papers by this author, ROBERT E. RYDELL, M.D.Search for more papers by this author, ALFRED EICHENHOLZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-4-521 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWegener's granulomatosis is a rare disease characterized by necrotizing, granulomatous lesions of the respiratory system, disseminated arteritis, and terminal glomerulonephritis (1). The syndrome was first reported by Klinger in 1931 (2). Wegener's reports of "rhinogenous granuloma" appeared in 1936 and 1939 (3, 4). In 1961, Lansdown reported 51 confirmed cases (5). The following 4 case reports are presented to illustrate the features of the disease and its similarity to periarteritis nodosa, rheumatoid arthritis, and anaphylactoid purpura.CASE REPORTSCASE 1R. G., a 25-year-old plaster-finisher, was admitted to the Minneapolis Veterans Hospital, January 12, 1949. Six weeks earlier he had...References1. FAHEYLEONARDCHURGGODMAN JLEJG: Wegener's granulomatosis. Amer. J. Med. 17: 168, 1954. CrossrefMedlineGoogle Scholar2. KLINGER H: Grenzformen der Periarteritis nodosa, Frankfurt Z. Path. 42: 455, 1931. Google Scholar3. WEGENER F: Über generalisierte septische Gefasserkrankungen. Verh. Deutsch. Ges. Path. 29: 202, 1936. Google Scholar4. WEGENER F: Über eine eigenartige rhinogene Granulomatose mit besonderer Beteiligung des Arterien-Systems und der Nieren. Beitr. Path. Anat. 102: 36, 1939. Google Scholar5. LANSDOWN FS: Necrosing granuloma of the lung. Amer. Rev. Resp. Dis. 84: 422, 1961. MedlineGoogle Scholar6. KUSSMAULMAIER AR: Über eine bisher nicht beschriebene eigenthümliche Arterienerkrankung (Periarteritis nodosa) die mit Morbus Brightii und rapid fortschreitender allgemeiner Muskellähmung einhergeht. Deutsch. Arch. Klin, Med. 1: 484, 1866. Google Scholar7. HEALKENT FCG: Purpura fulminans with afibrinogenemia. Canad. Med. Ass. J. 69: 367, 1953. MedlineGoogle Scholar8. LINDSAYAGGELERLUCIA SPMSP: Chronic granuloma associated with periarteritis nodosa; report of case with renal failure. Amer. J. Path. 20: 1057, 1944. MedlineGoogle Scholar9. KINNEYOLSENHEPPERHARRISON VRAMNGEG: Wegener's granulomatosis. Arch. Intern. Med. (Chicago) 108: 269, 1961. CrossrefMedlineGoogle Scholar10. SOKOLOFF L: Some aspects of the pathology of collagen diseases. Bull. N. Y. Acad. Med. 32: 760, 1956. MedlineGoogle Scholar11. ANGEVINE DM: The pathogenesis of polyarteritis, in Inflammation and Diseases of Connective Tissue, ed. by MILLS, L. C. and MOYER, J. H., W. B. Saunders Company, Philadelphia, 1961, p. 217. Google Scholar12. FIENBERG R: Pathergic granulomatosis. Amer. J. Med. 19: 829, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnestoaFrom the Departments of Medicine and Pathology, Veterans Administration Hospital, and the University of Minnesota Medical School, Minneapolis, Minnesota.Requests for reprints should be addressed to David A. Berman, M.D., 1047 Medical Arts Building, Minneapolis 2, Minnesota. 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