Revista da Sociedade Brasileira de Medicina Tropical · 2002 · 18 citations · 37 references
Veterinary MedicineImmunologyInfectious DiseasesImmunology Of Infectious DiseasesVaccine ImmunologyVaccinologyAdaptive Immune Responses To ParasitesHost-parasite Immune InteractionsParasitic Disease PathogenesisProtozoan Host-parasite InteractionsProtozoan ImmunologyVaccinationAdaptive Immunity To Protozoan ParasitesLeishmania-specific T Cell ResponsesLeishmaniasis Of The SkinLeishmaniasis PathogenesisParasite Vaccine DevelopmentParasite VaccinesProtective Correlates Of ImmunityProtozoal Vaccine Development
Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin(R) and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.
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Lloyd J. Old · Science · 1985 · 1.9K citations
Life Sciences, Immunology, Oncology +12
Two types of mouse helper T-cell clone
Tim R. Mosmann, Robert L. Coffman · Immunology Today · 1987 · 806 citations