Journal of Liquid Chromatography · 1984 · 18 citations · 7 references
PharmacyPharmacokineticsPharmacologyBiochemical PharmacologyChromatographic AnalysisClinical PharmacologyAnalytical ChromatographyChromatographic Analysis Of PharmaceuticalsChromatographic Data AnalysisChromatographyDrug DispositionLiquid ChromatographyAnalytical Liquid ChromatographyChromatographic Drug AnalysisDetection Limit AssessmentInternal Standard AnalysisMethod Detection LimitPharmacokinetic Parameter AnalysisPharmacokinetic ParametersPrecision
Abstract Cinnarizine is determined in whole blood and plasma by reversed phase HPLC on a RP-18 stationary phase. The one-step extraction is performed with a chloroform/hexane (2/3) mixture. A high recovery of 91% and a detection limit of 2 ng/ml are obtained as well as a good precision. The internal standard is meclozine. Pharmacokinetic parameters found are in accordance with data cited in literature.
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