Concepedia

VEGF-induced choroidal damage in a murine model of retinal neovascularisation

Lisa Tee, Marissa A. Penrose, J. E. O’Shea, C-M Lai, Elizabeth Rakoczy, Sarah A. Dunlop

British Journal of Ophthalmology · 2008 · 16 citations · 23 references

DOI

Abstract

We show that elevated retinal VEGF levels trigger pathophysiological changes in the choroid. We suggest that therapies to prevent vascular damage in diabetes must target both the retinal and choroidal vasculatures.

References

23

Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition

Kazuaki Miyamoto, Samer Khosrof, Sven–Erik Bursell et al. · Proceedings of the National Academy of Sciences · 1999 · 783 citations · Full text

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Transgenic Mice with Increased Expression of Vascular Endothelial Growth Factor in the Retina: A New Model of Intraretinal and Subretinal Neovascularization.

N. Okamoto, Takao Tobe, Sean F. Hackett et al. · Retina · 1998 · 367 citations

, , +16

High-resolution histologic analysis of the human choroidal vasculature.

D. Scott McLeod, Gerard A. Lutty · PubMed · 1994 · 262 citations

Intrachoroidal Neovascularization in Transgenic Mice Overexpressing Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium

Catherine Schwesinger, Charles Yee, Richard M. Rohan et al. · American Journal Of Pathology · 2001 · 226 citations · Full text

, , +8

Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition

K. Miyarnoto · Proc Natl Acad Sci USA · 1999 · 207 citations

, , +10