Arylation and 1-Alkenylation on α-Position of Ketones <i>via</i> Tributyltin Enolates Catalyzed by Palladium Complex

Abstract

Abstract The reaction of tributyltin enolates, prepared from tributyltin methoxide and enol acetates in situ, with aryl and 1-alkenyl bromides in the presence of dichlorobis(tri-o-tolylphosphine)palladium was found to give α-aryl and α-(1-alkenyl) ketones, respectively, in good yields with essentially complete retention of the enol acetate regiochemistry.