Canadian Journal of Physiology and Pharmacology · 1967 · 12 citations · 0 references
PharmacyPharmacologyToxicologyNeurotoxicologyPharmaceutical ToxicologyTransdermal Drug DeliveryChemical Penetration EnhancersSkin Barrier FunctionSkin IrritationGuinea Pig ModelsPenetration RatePhysical Penetration EnhancementRate Of Penetration EffectsSkin Barrier PenetrationSkin Penetration PathophysiologyStratum Corneum PermeabilityStratum Corneum Structure
The penetration of both intact and stripped guinea pig skin by soman was enchanced by dimethyl sulfoxide (DMSO), showing that DMSO does not act solely by increasing the penetration of stratum corneum. At high concentrations of DMSO the increase in penetration was masked by a decrease in the spreading of the mixtures on skin, but when this decrease was taken into consideration the penetration rate of soman increased with increasing DMSO concentrations up to at least 90%.