Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator

Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

Magdalena Juhaszova, Dmitry B. Zorov, Suhn-Hee Kim et al. · Journal of Clinical Investigation · 2004 · 988 citations · Full text

Opening of Mitochondrial K_ATPChannels Triggers the Preconditioned State by Generating Free Radicals

Tilley Pain, Xi‐Ming Yang, Stuart D. Critz et al. · Circulation Research · 2000 · 662 citations · Full text

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

Roberto Bolli, Mohamed O. Jeroudi, Brijeshkumar S. Patel et al. · Circulation Research · 1989 · 582 citations

Heart Failure, Antioxidant Therapy, Pbn Adduct Production +16

Ischemic preconditioning protects by activating prosurvival kinases at reperfusion

Derek J. Hausenloy, Andrew Tsang, Mihaela Mocanu et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2004 · 499 citations

Oxygen Radicals Released During Ischemic Preconditioning Contribute to Cardioprotection in the Rabbit Myocardium

Christopher Baines, Mahiko Goto, James M. Downey · Journal of Molecular and Cellular Cardiology · 1997 · 483 citations

Heart Failure, Cardiogenic Shock, Cardiovascular Disease +12