Possible contribution of CD44 variant 6 and nuclear ?-catenin expression to the formation of budding tumor cells in patients with T1 colorectal carcinoma

Abstract

The current results suggest that the up-regulation of CD44 variant 6 through nuclear beta-catenin activation may contribute to the formation of tumor budding, and immunostaining of these two adhesion molecules may be useful in identifying those at high-risk for locoregional failure among patients with T1 colorectal carcinoma.