Concepedia

Peripheral blood CD4+CD25+CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

Jun Kikuchi, Misato Hashizume, Yuko Kaneko, Keiko Yoshimoto, Naoshi Nishina, Tsutomu Takeuchi

Arthritis Research & Therapy · 2015 · 118 citations · 24 references

DOIFull text

Open access

Abstract

This study demonstrates that TCZ affected proportions of circulating immune cells in patients with RA. The proportion of Treg cells among CD4(+) cells correlated well with clinical response.

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