Synthesis of Metabolites of the Prodrug 2,5-Bis(4-O-methoxyamidinophenyl)furan

Abstract

The synthesis of three metabolites of the prodrug 2,5-bis-(4-O-methoxyamidinophenyl)furan (1), 2-(4-hydroxyamidinophenyl)-5-(4-methoxyamidinophenyl)furan (M1), 2-(4-amidinophenyl)-5-(4-ethoxyamidinophenyl)furan (M3) and 2-(4-amidinophenyl)-5-(4-hydroxyamidinophenyl)furan (M4), is reported.The key step in each of the syntheses involves the Heck reaction.