Concepedia

The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models

Nicolas Faur, L Araud, Audrey Laroche‐Clary, Jun Kanno, Jérôme Toutain, Takao Yamori, Jacques Robert, Valérie Le Morvan

British Journal of Cancer · 2009 · 14 citations · 28 references

DOIFull text

Open access

Abstract

We hypothesised that cell lines harbouring the MDM2 G allele presented a lower availability of p53 for DNA repair, translating into higher sensitivity to DNA-damaging agents.

References

28

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