The Role of K+ Channels on the Inhibitor Effect of Sevoflurane in Pregnant Rat Myometrium

Haluk Kafal, Tijen Kaya, Sinan Gürsoy, İhsan Bağcıvan, Bars Karadas, Yusuf Sarıoğlu

Anesthesia & Analgesia · 2002 · 28 citations · 19 references

Abstract

In this study, we found that sevoflurane causes significantly decreased myometrial contractile activity in pregnant rats. The inhibition of myometrial smooth muscle induced by sevoflurane seems to be mediated, at least in part, via activation of Ca(2+)-activated K(+) channels, because inhibition was reduced by tetraethylammonium.

References

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