Helvetica Chimica Acta · 1970 · 12 citations · 6 references
Chemical EngineeringPharmaceutical ChemistryEngineeringPharmaceutical ScienceBiochemistryDerivative (Chemistry)MedicineTemperature DependenceOrganic ChemistryReactivity (Chemistry)Synthetic ChemistryChemistryPharmacologyChemical KineticsAbstract PhenylbutazoneSolution (Chemistry)Reversible ReactionDrug Analysis
Abstract Phenylbutazone (I) forms in aqueous and partially aqueous solution butylmalonic acid mono (N, N′‐diphenylhydrazide) (II) by a reversible reaction. The reaction rate and the position of equilibrium depend on the solvent but practically not on the pH. The temperature dependence is given for several media. Substituents affect the reaction rate when they are in 4‐position but not in 4′‐ or 4″‐position. Based on the kinetic data, a reaction mechanism is proposed. Methods for the analysis of I in mixtures with II are presented. The preparation of II is described.
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