Concepedia

Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity

Daniela Sporrer, Markus Weber, Josef Wanninger, Johanna Weigert, Michael Neumeier, Fabian Stögbauer, Evelyn Lieberer, M. Bala, A. Kopp, Andréas Schäffler,

European Journal of Clinical Investigation · 2009 · 52 citations · 29 references

Abstract

This study indicates that monocytic CD163 and systemic sCD163 are elevated in T2D and obesity. Adiponectin reduces CD163 in vitro, but additional factors related to obesity like IL-6 may be more relevant in vivo.

References

29

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

Yukio Arita, Shinji Kihara, Noriyuki Ouchi et al. · Biochemical and Biophysical Research Communications · 1999 · 4.8K citations

Obesity, Metabolic Syndrome, Metabolic Disorder +8

Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

Justin I. Odegaard, Roberto R. Ricardo-González, Matthew H. Goforth et al. · Nature · 2007 · 2K citations · Full text

Insulin Resistance, Metabolic Syndrome, Insulin Signaling +9

Identification of the haemoglobin scavenger receptor

Mette Kristiansen, Jonas Heilskov Graversen, Christian Jacobsen et al. · Nature · 2001 · 1.7K citations

Haemoglobin Scavenger Receptor, Physiology, Hematology +5

Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes

Anna Wolf, Dominik Wolf‎, Holger Rumpold et al. · Biochemical and Biophysical Research Communications · 2004 · 822 citations

Inflammation, Metabolic Syndrome, Cytokine +10

Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

Duygu Sağ, David Carling, Robert D. Stout et al. · The Journal of Immunology · 2008 · 787 citations · Full text