Concepedia

Formal Catalytic Asymmetric Total Synthesis of Fostriecin

Kunihiko Fujii, Keisuke Maki, Motomu Kanai, Masakatsu Shibasaki

Organic Letters · 2003 · 119 citations · 16 references

DOI

Concepts

Abstract

The common synthetic intermediate of a potent and promising anticancer agent, fostriecin, was synthesized using a unique method that combines four catalytic asymmetric reactions as shown above.

References

16

Recent advances in olefin metathesis and its application in organic synthesis

Robert H. Grubbs, Sukbok Chang · Tetrahedron · 1998 · 2.1K citations

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Asymmetric Transfer Hydrogenation of α, β-Acetylenic Ketones

Kazuhiko Matsumura, Shohei Hashiguchi, Takao Ikariya et al. · Journal of the American Chemical Society · 1997 · 708 citations

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Direct Catalytic Asymmetric Aldol Reaction

Naoki Yoshikawa, Yoichi M. A. Yamada, Jagattaran Das et al. · Journal of the American Chemical Society · 1999 · 373 citations

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Catalytic Enantioselective Cyanosilylation of Ketones

Yoshitaka Hamashima, Motomu Kanai, Masakatsu Shibasaki · Journal of the American Chemical Society · 2000 · 260 citations

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Switching Enantiofacial Selectivities Using One Chiral Source:  Catalytic Enantioselective Synthesis of the Key Intermediate for (20<i>S</i>)-Camptothecin Family by (<i>S</i>)-Selective Cyanosilylation of Ketones

Kazuo Yabu, Shuji Masumoto, Shingo Yamasaki et al. · Journal of the American Chemical Society · 2001 · 235 citations

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