Concepedia

APC Genotype, Polyp Number, and Surgical Options in Familial Adenomatous Polyposis

James S. Wu, Philip Paul, Ellen McGannon, James M. Church

Annals of Surgery · 1998 · 178 citations · 19 references

DOI

Abstract

Our data support an association between severe polyposis phenotype and mutations at APC gene codons 1309 and 1328. For patients with these mutations, the prognosis for retaining the rectum is poor.

References

19

A simple salting out procedure for extracting DNA from human nucleated cells

S.A. Miller, Dale D. Dykes, Herbert F. Polesky · Nucleic Acids Research · 1988 · 20.4K citations · Full text

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Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences · 1989 · 3.6K citations · Full text

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Identification and characterization of the familial adenomatous polyposis coli gene

Joanna Groden, Andrew Thliveris, Wade S. Samowitz et al. · Cell · 1991 · 2.8K citations

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Identification of FAP Locus Genes from Chromosome 5q21

Kenneth W. Kinzler, Mef Nilbert, Li-Kuo Su et al. · Science · 1991 · 2.4K citations

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Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

S Munemitsu, Iris Albert, Brígida Souza et al. · Proceedings of the National Academy of Sciences · 1995 · 1K citations · Full text

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