<i>Escherichia coli</i> Nissle 1917 Facilitates Tumor Detection by Positron Emission Tomography and Optical Imaging

Abstract

EcN can be imaged by PET, based on the expression of endogenous E. coli thymidine kinase, and this imaging paradigm could be translated to patient studies for the detection of solid tumors. Bioluminescence imaging provides a low-cost alternative to PET imaging in small animals.