Intravenous versus  Nebulized Ceftazidime in Ventilated Piglets with and without Experimental Bronchopneumonia

Abstract

Nebulization of ceftazidime induced a 5- to 30-fold increase in lung tissue concentrations as compared with intravenous administration. Using a helium-oxygen mixture as the carrying gas of the aerosol induced a substantial additional increase in lung deposition in noninfected piglets but not in piglets with experimental bronchopneumonia.