TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway

IL-10 inhibits cytokine production by activated macrophages

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IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells

David Fiorentino, Albert Zlotnik, Paulo Vieira et al. · The Journal of Immunology · 1991 · 1.9K citations · Full text

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Hans Häcker, Vanessa Redecke, Blagoy Blagoev et al. · Nature · 2005 · 972 citations · Full text

Inflammation, Toll-like Receptors, Molecular Immunology +12

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

Lin Liu, Istvan Botos, Yan Wang et al. · Science · 2008 · 708 citations · Full text

Crystal Structure, Engineering, Innate Immune System +18

IFN-γ Suppresses IL-10 Production and Synergizes with TLR2 by Regulating GSK3 and CREB/AP-1 Proteins

Xiaoyu Hu, Paul K. Paik, Janice Chen et al. · Immunity · 2006 · 404 citations · Full text

Inflammation, Cytokine, Immunology +11