Concepedia

Glycoprotein transmembrane nmb: An androgen‐downregulated gene attenuates cell invasion and tumorigenesis in prostate carcinoma cells

Ke‐Hung Tsui, Ying‐Ling Chang, Tsui‐Hsia Feng, Phei‐Lang Chang, Horng‐Heng Juang

The Prostate · 2012 · 24 citations · 41 references

DOI

Abstract

Together these results suggest that GPNMB gene is a p53- and androgen-dysregulated gene and should be regarded as an anti-tumor gene for prostate cancer. The enhancement of Ndrg1 and maspin gene expressions may account for the anti-proliferative and anti-invasive function of GPNMB in PC-3 cells.

References

41

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Intraprostatic Androgens and Androgen-Regulated Gene Expression Persist after Testosterone Suppression: Therapeutic Implications for Castration-Resistant Prostate Cancer

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The Drg-1 gene suppresses tumor metastasis in prostate cancer.

Sucharita Bandyopadhyay, Sudha K. Pai, Steven Gross et al. · PubMed · 2003 · 313 citations

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<i>nmb</i>, a novel gene, is expressed in low‐metastatic human melanoma cell lines and xenografts

Marian A. J. Weterman, N.E. Ajubi, Irma M. R. van Dinter et al. · International Journal of Cancer · 1995 · 249 citations · Full text

Non-Small-Cell Lung Cancer Molecular Signatures Recapitulate Lung Developmental Pathways

Alain Borczuk, Lyall A. Gorenstein, Kristin Walter et al. · American Journal Of Pathology · 2003 · 210 citations · Full text

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