Adriamycin Activating a Recall Phenomenon After Radiation Therapy

Abstract

Letters1 September 1974Adriamycin Activating a Recall Phenomenon After Radiation TherapySARAH S. DONALDSON, M.D., JANE M. GLICK, PH.D., JORDAN R. WILBUR, M.D.SARAH S. DONALDSON, M.D.Search for more papers by this author, JANE M. GLICK, PH.D.Search for more papers by this author, JORDAN R. WILBUR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-3-407 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Adriamycin has antineoplastic activity in malignant lymphomas, bone and soft tissue sarcomas, neuroblastomas, and some carcinomas (1). Toxicity reported includes leukopenia, stomatitis, mucositis, nausea, vomiting, alopecia, and cardiomyopathy (1). There are no reports of a "recall phenomenon," reactivation of latent radiation effects in a previously irradiated field, with adriamycin, similar to those recognized with actinomycin D.We have now seen two children who have had such a "recall phenomenon" associated with the administration of adriamycin. With increasing use of adriamycin combined with irradiation in solid tumor therapy, we believe our observations may be important to others.A...References1. BLUMCARTER RS: Adriamycin. A new anticancer drug with significant clinical activity. Ann Intern Med 80:249-259, 1974 LinkGoogle Scholar2. D'ANGIOFARBERMADDOCK GSC: Potentiation of x-ray effects by actinomycin D. Radiology 73:175-177, 1959 CrossrefMedlineGoogle Scholar3. SOBELL H: The stereochemistry of actinomycin binding to DNA. Cancer Chemother Rep 58:101-116, 1974 MedlineGoogle Scholar4. SCHWARTZ H: Some determinants of the therapeutic efficacy of actinomycin D (NSC-3053), adriamycin (NSC-123127), and daunorubicin (NSC-83142). Cancer Chemother Rep 58:55-62, 1974 MedlineGoogle Scholar5. BYFIELD J: Repair of low dose radiation damage to human epidermoid carcinoma cells (abstract). Proc Am Assoc Cancer Res 14:61, 1973 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SARAH S. DONALDSON, M.D.; JANE M. GLICK, PH.D.; JORDAN R. WILBUR, M.D.Affiliations: Departments of Radiology and Pediatrics Stanford University School of Medicine Stanford, California 94305 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRadiation Recall Pneumonitis COVID-19 Infection Induced After Adjuvant Breast Cancer Radiotherapy. 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EAGAN, M.D., ROBERT E. LEE, M.D., DAVID T. CARR, M.D.Simultaneous radiation and drug therapy: Tumor response and toxicityToxicity of Chemotherapeutic AgentsPrinciples of Combination ChemotherapyComplications of irradiation related to apparent drug potentiation by adriamycinAdriamycin and Enhanced Radiation Reaction in Normal Esophagus and SkinF. ANTHONY GRECO, M.D., HARMAR D. BRERETON, M.D., HARRY KENT, M.D., HARVEY ZIMBLER, M.D., JOHN MERRILL, M.D., RALPH E. JOHNSON, M.D.Skin ulcers due to adriamycinDaunomycin, Adriamycin, and Recall EffectDAVID BAER, M.D., LEE S. WILKINSON, M.D.Decreased risk of radiation-associated second malignant neoplasms in actinomycin-d-treated patientsQuantification of combined radiation therapy and chemotherapy effects on critical normal tissuesAcute and late effects on normal tissues following combined chemo- and radiotherapy for childhood rhabdomyosarcoma and Ewing's sarcomaCure has its tomorrowsSTOOL WEIGHTS IN NORTH INDIANSPIGEON ERYTHROCYTES FOR RUBELLA HÆMAGGLUTINATION INHIBITION TESTSDOXORUBICIN, RADIOTHERAPY, AND ŒSOPHAGEAL STRICTURERecall Injury from AdriamycinSTEPHEN C. COHEN, M.D., NICHOLAS J. DIBELLA, M.D., JOHN C. MICHALAK, M.D.Chemotherapy of sarcomasModification of radiation injury to normal tissues by chemotherapeutic agentsHead and Neck 1 September 1974Volume 81, Issue 3Page: 407-408KeywordsBoneCardiomyopathiesChildrenLymphomaNauseaNeuroblastomaRadiation therapySarcomaToxicityVomiting ePublished: 1 December 2008 Issue Published: 1 September 1974 PDF downloadLoading ...