A COMPARISON OF THE ACUTE EFFECTS OF CORTICOSTERONE AND 17-HYDROXYCORTICOSTERONE ON BODY WEIGHT AND THE URINARY EXCRETION OF SODIUM, CHLORIDE, POTASSIUM, NITROGEN AND GLUCOSE IN THE NORMAL RAT

Abstract

THE PURPOSE of this study was to further evaluate the differences in the biologic properties of corticosterone and its C-17-oxygenated derivative. At a dosage level of 5 mgm. per day, each compound caused glycosuria in some of the animals and an increase in the excretion of sodium, chloride, potassium and nitrogen. The 17-oxygenated compound caused the greatest response. At smaller doses 17-hydroxycorticosterone, but not corticosterone, caused an increased sodium excretion, and the former compound had a greater effect on weight and nitrogen balance.