A simple preparation of syn-NH-amide aldols and amide-Baylis–Hillman adducts via a Michael–aldol tandem process

Abstract

The thiolate- or selenolate-induced Michael–aldol tandem process using secondary α,β-unsaturated amides gave α-phenylthio- or α-phenylseleno-methyl-β-hydroxy amides syn-selectively, which were readily converted into NH-amide aldols or Baylis–Hillman adducts.