Pharmakologisch‐aktive polymere, 21. Orientierende Untersuchungen zur körperverteilung und Ausscheidung von poly[2‐(methylsulfinyl)ethylacrylat]en bei der Ratte

Abstract

Abstract Poly[2‐(methylsulfinyl)ethyl acrylate] ( 1 ) was synthesized as well as derivatives 14 C‐labelled in side groups ( 6 ) or 14 C‐labelled in the main chain ( 11 ). Polymer 11 with the 14 C‐labelled main chain was fractionated by precipitation. The η‐ M ‐relation determined by measurements of unlabelled polymers in the ultracentrifuge for comparison was used to establish the viscosimetrically determined molecular weights of the labelled fractions. After intravenous application of aqueous solutions of the polymer in rats the excretion rate up to 72 h after treatment was ascertained to ca. 50%; the concentration in the blood serum was found to be strikingly high. A tendency to reinforced storage in organs of high phagocytose activity by growing molecular weight was observed. The tumor affinity was — if at all — low.