Science · 1989 · 439 citations · 24 references
Life SciencesGeneticsMolecular GeneticsAntimicrobial ResistanceComparative GenomicsMedical GeneticsAntiparasitic Drug ResistanceDrug ResistanceDrug Resistance GenomicsMolecular Basis Of ResistanceResistance GenesTherapeutic ResistanceGene Amplification In ResistanceMalaria GenomicsMalaria ResistanceMolecular Drug ResistanceParasite Drug ResistancePlasmodium FalciparumProtozoan Drug Resistance GeneticsResistance Mechanisms In Parasites
The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.
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Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations