Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant <i>Plasmodium falciparum</i>

Abstract

The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.