Synthesis of the First Ferrocenyl Derivatives of Curcuminoids

Abstract

The synthesis of curcuminoids covalently bound to a ferrocenyl moiety was investigated using two strategies: a ferrocenyl unit was incorporated during the synthesis of 3,4-dimethylcurcumin using a Knoevenagel condensation, and the enolates of 3,5-dimethylcurcumin and curcumin, previously protected, underwent a 1,4-addition on ferrocenyl propynone.