European Journal of Gastroenterology & Hepatology · 1994 · 35 citations · 0 references
MedicineInfectious DiseasesPediatricsAntimicrobial PharmacotherapyGastroenterologyPediatric GastroenterologyAntimicrobial Agent SelectionGastric DiseasesHelicobacter Pylori Eradication TherapyPediatric Antimicrobial TherapyPeptic Ulcer DiseasePeptic Ulcer Disease CareEradicationGastric Ulcer DiseaseHelicobacter Pylori EradicationHelicobacter Pylori InfectionHelicobacter Pylori TestingPediatric Eradication TherapyPediatric Peptic Ulcer DiseasePeptic Ulcer Disease Eradication
Objective. To investigate the efficacy of several regimens directed against Helicobacter pylori. Design. A series of open studies concerning 850 courses of anti-H. pylori therapy. Setting. Outpatient department in a large university hospital. Patients. Patients who underwent endoscopy because of dyspeptic complaints with or without endoscopie evidence of peptic ulcération. Main outcome measures. Culture and histology of antral biopsy specimens for determination of H. pylori status. Results. Monotherapy with colloidal bismuth subcitrate (CBS) or antibiotics resulted in eradication rates of 8–24%. Combinations of CBS and one antibiotic eradicated H. pylori in 11–69% of patients. If CBS was combined with two antibiotics, eradication rates of 39–85% were obtained. Omeprazole combined with amoxycillin/clavulanate eradicated H. pylori in 55% of patients. The presence of metronidazole-resistant strains predicted a poor outcome for therapies containing metronidazole. Conclusions. Although H. pylori infection can be treated effectively, a simple, safe and efficient regimen has yet to be developed.