Heterogeneity of DSM-IV Major Depressive Disorder as a Consequence of Subthreshold Bipolarity

Abstract

Data suggest that MDD is a heterogeneous concept including a large group with subthreshold BPD, which is clinically significant and shares similarities with BPD. Findings might support the need for a broader concept and a more comprehensive screening of bipolarity, which could be substantial for future research and adequate treatment of patients with bipolarity.