Journal of Clinical Pathology · 1988 · 49 citations · 31 references
MedicineOncologyPathologyCytopathologyHematologic OncologyNeoplasiaHematologic MalignanciesLymphoid NeoplasmsLymphoid TumorsMalignant NeoplasmsMolecular CytopathologyTumor CytopathologyAneuploidy AnalysisFlow Cytometric AnalysisLymphoid Neoplasm PrognosisMitotic Activity AssessmentMitotic AneuploidyMitotic Count EvaluationMultiple RegressionProliferative Index
The prognostic importance of ploidy and proliferative index (%S + G2) assessed by flow cytometry, mitotic and centroblast counts, and histological growth pattern were evaluated in biopsy specimens taken before treatment from 60 cases of centroblastic-centrocytic non-Hodgkin's lymphoma. Cases with a high proliferative index (greater than or equal to 18%) or DNA aneuploidy showed significantly poorer survival than those with a low proliferative index (less than 18%). A high mitotic count was also associated with a poor prognosis. On multiple regression analysis the flow cytometric assessments and mitotic counts were significant predictors of survival. Assessments of proliferative activity clearly have prognostic potential in centroblastic-centrocytic lymphoma and may permit more accurate characterisation of individual tumours.
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Convention on nomenclature for DNA cytometry
Wolfgang Hiddemann, J. Schumann, Michael Andreeff et al. · Cytometry · 1984 · 594 citations · Full text