The effect of alismol isolated from alismatis rhizoma on experimental hypertensive models in rats

Abstract

Abstract The antihypertensive action of alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, the rhizome of Alisma orientale Juzepczuk (Alismataceae), was examined in various experimental hypertensive models in rats and the effect of alismol on the activation of plasma renin, angiotensin‐converting enzyme (ACE) and the level of aldosterone were examined in 2‐kidney, 1‐clip hypertensive model. Alismol caused a sustained, though weak, antihypertensive action in all the experimental models, but did not significantly affect the plasma renin activity, ACE activity and the level of aldosterone.