Phytotherapy Research · 1989 · 10 citations · 5 references
MedicinePharmacologyPlant SciencesExperimental PharmacologyGeneral PharmacologyPlant PhysiologyBlood Pressure ManagementCardiovascular PharmacologyHypertension ManagementHypertension PharmacotherapyRenal PharmacologyAntihypertensive Drug TherapyAntihypertensive PharmacologyAntihypertensive TreatmentPlasma Renin ActivityRenin-angiotensin System ModulationRenin-angiotensin-aldosterone System Activation
Abstract The antihypertensive action of alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, the rhizome of Alisma orientale Juzepczuk (Alismataceae), was examined in various experimental hypertensive models in rats and the effect of alismol on the activation of plasma renin, angiotensin‐converting enzyme (ACE) and the level of aldosterone were examined in 2‐kidney, 1‐clip hypertensive model. Alismol caused a sustained, though weak, antihypertensive action in all the experimental models, but did not significantly affect the plasma renin activity, ACE activity and the level of aldosterone.
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