2‐Pyrrolidinecarboxylic Acid Ionic Liquid as a Highly Efficient Organocatalyst for the Asymmetric One‐Pot Mannich Reaction

Abstract

Abstract A novel one‐pot three‐component asymmetric Mannich reaction using [EMIm][Pro] ( 1 ) as a catalyst has been developed. By employing this new reaction system, a variety of optically active β‐amino carbonyl compounds were synthesized in up to 99 % yield with up to >99 dr and >99 % ee . The reaction conditions have been optimized and the mechanism for the asymmetric induction is discussed.