I₂-Mediated Oxidative Cyclization for Synthesis of Substituted Indolizines

Abstract

A direct method for the synthesis of substituted indolizines by means of I2-mediated oxidative tandem cyclization via C-N/C-C bond formation was developed. Various substituted aromatic/aliphatic enolizable aldehydes and 2-pyridylacetates/acetonitrile/acetone proceeded smoothly in this transformation, and the desired products were generated in moderate to good yields.