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An Unexpected Coupling – Isomerization Sequence as an Entry to Novel Three-Component-Pyrazoline Syntheses
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Palladium/copper-catalyzed Cross-couplingCross-coupling ReactionNovel Retrosynthetic ApproachEnone CyclocondensesEngineeringBiochemistryNatural SciencesOrganic ChemistryCatalysisStereoselective SynthesisChemistryHeterocycle ChemistryPharmacologyAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringNovel Three-component-pyrazoline Syntheses
A novel retrosynthetic approach to 3,5-diaryl-2-pyrazolines is provided by a three-component, one-pot reaction initiated by a palladium/copper-catalyzed cross-coupling (see scheme). The initially formed enone cyclocondenses in situ with the hydrazine to furnish the heterocycle. EWG=electron-withdrawing group.