Effect of the Protein Matrix of Cytochromec in Suppressing the Inherent Peroxidase Activity of Its Heme Prosthetic Group

Abstract

Unraveling enzyme activity: Unfolding of the electron-transfer protein cytochrome c-550 results in a spectacular increase in its peroxidase activity (see graph). This finding is interpreted in terms of the suppression by the cytochrome protein matrix of the potentially harmful peroxidase activity inherent to its heme cofactor.