Journal of Natural Products · 2004 · 53 citations · 2 references
Natural SciencesPharmacologyToxicologyCancer PharmacologyDrug DiscoveryStructure-activity RelationshipsMarine Bioactive CompoundsMarine Natural ProductsMarine PharmacologyReef-building Coral BiologyReef-building CoralsTerpenoid BiosynthesisAnticancer Marine CompoundsBioactive Compounds From Marine CoralsBioactive Compounds From Marine FungiBioactive Marine MetabolitesMarine Sponge MetabolitesSoft Coral BiologySoft Coral MetabolitesSoft Corals As Drug Sources
Five new nardosinane sesquiterpenoids, armatins A-E, lemnal-1(10)-ene-2,12-dione (a new natural product), and two new cytotoxic 19-oxygenated ergosterols, armatinols A and B, were isolated from the methylene chloride extract of the soft coral Nephthea armata, collected in Taiwan. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity was determined against selected cancer cells.
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