The anthelmintic effects of flubendazole on Trichuris trichiura and Ascaris iumbricoides

Abstract

Flubendazole is an effective anthelmintic against both Trichuris trichiura and Ascaris lumbricoides. Single doses of 200 mg, 500 mg and 600 mg flubendazole, or two doses of 300 mg flubendazole on two consecutive days, effectively reduced egg output of both helminths by over 90%. Cure rates of 90.0 to 97.0% were obtained in Ascaris infections but only 17.3 to 65.1% of Trichuris infections were completely cured with the various single-dose or two-dose regimes. Flubendazole did not cause erratic migration of Ascaris in mixed infections at any of the dosages used.