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The FDA Warning on Antidepressants and Suicidality — Why the Controversy?

Marc B. Stone

New England Journal of Medicine · 2014 · 45 citations · 6 references

DOIFull text

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Abstract

Since the 2004 FDA decision to require a boxed warning on antidepressants regarding the risk of suicidality in children and adolescents, people who feared adverse consequences of that decision have found support for their view in various seriously flawed studies.

References

6

Early Evidence on the Effects of Regulators’ Suicidality Warnings on SSRI Prescriptions and Suicide in Children and Adolescents

Robert D. Gibbons, C. Hendricks Brown, Kwan Hur et al. · American Journal of Psychiatry · 2007 · 608 citations

, , +17

Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study

Christine Y. Lu, Fan Zhang, Matthew Lakoma et al. · BMJ · 2014 · 232 citations · Full text

, , +16

Antidepressants' Black-Box Warning — 10 Years Later

Richard A. Friedman · New England Journal of Medicine · 2014 · 179 citations · Full text

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Persisting Decline in Depression Treatment After FDA Warnings

Anne M. Libby, Heather D. Orton, Robert J. Valuck · Archives of General Psychiatry · 2009 · 157 citations

, , +16

Spillover Effects on Treatment of Adult Depression in Primary Care After FDA Advisory on Risk of Pediatric Suicidality With SSRIs

Robert J. Valuck, Anne M. Libby, Heather D. Orton et al. · American Journal of Psychiatry · 2007 · 138 citations

, , +16