FEBS Letters · 2010 · 427 citations · 12 references
Life SciencesGeneticsMolecular BiologyGene ExpressionMetastasisTranscriptional RegulationCancer ProgressionLung MetastasisNoncoding Rna BiologyNoncoding Rna In CancerRna InterferenceSmall Interfering Rna BiologyAltered Cell MotilityCell Migration DynamicsGene Silencing In CancerLung AdenocarcinomaMetastatic SignalingNoncoding Rna In MetastasisNoncoding Rna-mediated Gene RegulationTumor Cell Motility
MALAT-1, a long non-coding RNA, is associated with metastasis, but its role in the metastatic process remains unknown. Here, we show that short-interfering RNA-mediated MALAT-1 silencing impaired in vitro cell motility of lung cancer cells and influenced the expression of numerous genes. In these genes, knockdown of any one of CTHRC1, CCT4, HMMR, or ROD1 clearly inhibited cell migration. In MALAT-1 knockdown cells, pre-mRNA levels were decreased in some but not all genes. Thus, our findings suggest that MALAT-1 is a novel class of non-coding RNA that promotes cell motility through transcriptional and post-transcriptional regulation of motility related gene expression.
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RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive Transcription
Philipp Kapranov, Jill Cheng, Sujit Dike et al. · Science · 2007 · 2.6K citations