Human Psychopharmacology Clinical and Experimental · 2005 · 37 citations · 21 references
PharmacyHealth SciencesGerontologyHealth AssessmentPsychometricsHealth Outcomes MeasurementHealth Status MeasurementHealth-related Quality Of LifeHealth-related Quality Of Life MeasurementQuality Of LifeQuality Of Life AssessmentHealth Status IndicesLife Satisfaction MeasurementOccupational FunctioningQuality Of Life ImpairmentWell-being
STUDY OBJECTIVE: The purpose of this study was to determine subjective health-related quality of life (HRQoL) in a sample of the Austrian population over 14 years of age in order to evaluate the effect of socio-demographic variables on HRQoL. DESIGN/SETTING: HRQoL was determined by means of the quality of life index-German version (QLI-Ge). The influence of socio-demographic variables on HRQoL was assessed by statistical analysis using the Kruskal-Wallis test and an analysis of variance. PARTICIPANTS: A random-quota procedure was used to get balanced representation from regions and demographic groups of the Austrian population. The sample consisted of 1049 participants, 493 men and 556 women. MAIN RESULTS: Age was found to influence the QLI-Ge total score (index score) and most individual items, with increasing age resulting in a decrease in HRQoL. Differences between the sexes were observed in three dimensions: males scored higher in 'physical well-being', 'psychological well-being' and 'occupational functioning'. Marital status impacted most items with married persons showing better values than divorced persons or singles. Profession had only a minor effect on HRQoL, the level of education showed no influence at all. CONCLUSIONS: The socio-demographic variables age, sex and objective living conditions had a major influence on subjectively rated HRQoL, whereas profession and education were found to play a minor role in this context. It is recommended that in the interpretation of studies assessing HRQoL the above-mentioned objective factors be considered. This will be of particular importance when determining the effect of a pharmacotherapy on HRQoL in patients.
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Quality of life and pharmacoeconomics in clinical trials
Joseph L. Pater · Controlled Clinical Trials · 1996 · 2.4K citations