Concepedia

Effective construction of quaternary stereocenters by highly enantioselective α-amination of branched aldehydes

Ji‐Ya Fu, Xiao‐Ying Xu, Yanchun Li, Qingchun Huang, Lixin Wang

Organic & Biomolecular Chemistry · 2010 · 46 citations · 62 references

DOI

Concepts

Abstract

A highly efficient enantioselective α-amination of branched aldehydes with azadicarboxylates promoted by chiral proline-derived amide thiourea bifunctional catalysts was developed for the first time, affording the adducts bearing quaternary stereogenic centers with excellent yields (up to 99%) and enantioselectivities (up to 97% ee).

References

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